Little Known Facts About cees dekker.

Little Known Facts About cees dekker.

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‘Sure, that is definitely about correct. I seek for a physical knowledge of Organic programs in a bottom-up way. I feel you could distinguish 3 strains of study in my group at the moment. The primary concerns chromosome construction: How would you receive a metre-lengthy DNA polymer folded and organised in this type of microscopic mobile? We have now formulated visualisation techniques that enable us to review how, such as, SMC proteins loop DNA (video on Youtube) in an effort to Establish up chromosomes.

Human Rad51 filaments on double- and single-stranded DNA: correlating normal and irregular types with recombination functionality.

Multicolor imaging of your bacterial nucleoid and mobile division proteins with blue, orange, and around-infrared fluorescent proteins

A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola

This yielded a breakthrough. Inside only some months, we had been able to measure transportation by means of an individual solitary-walled carbon nanotube. Based on lower-temperature experiments by a brilliant PhD college student in my group, Sander Tans (now a valued colleague and professor at Delft University of Technologies by having an active exploration lab at AMOLF in Amsterdam), we showed that carbon nanotubes have been legitimate quantum wires with really extensive (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.

Microbiology has only existed for just a century, since we started to study micro-organisms much more significantly. I believed nanobiology was an acceptable expression, mainly because all molecular Organic related interactions take place in the nanoscale: a protein is a couple of nanometres in sizing, DNA is two nm thick.’

All parameters were the identical for each panel With this online video, aside from the Original placement of the 6hb rod (shown in ceesdekker.net blue) within the nanopore. Simulations that terminated early on account of translocation of your rod in the pore are marked by a gray background.

Researching DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.

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Bulk-area coupling identifies the mechanistic relationship between Min-protein patterns in vivo and in vitro

Testing pseudotopological and nontopological versions for SMC-pushed DNA loop extrusion against roadblock-traversal experiments

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2013, controlled shaping of Are living bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations in the handedness of histone tetrasomes